Advances in Structure Modeling Methods for Cryo-Electron Microscopy Maps.
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ABSTRACT:
SUBMITTER: Alnabati E
PROVIDER: S-EPMC6982917 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Advances in Structure Modeling Methods for Cryo-Electron Microscopy Maps.
Alnabati Eman E Kihara Daisuke D
Molecules (Basel, Switzerland) 20191224 1
Cryo-electron microscopy (cryo-EM) has now become a widely used technique for structure determination of macromolecular complexes. For modeling molecular structures from density maps of different resolutions, many algorithms have been developed. These algorithms can be categorized into rigid fitting, flexible fitting, and de novo modeling methods. It is also observed that machine learning (ML) techniques have been increasingly applied following the rapid progress of the ML field. Here, we review ...[more]
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