Ontology highlight
ABSTRACT:
SUBMITTER: Muhseen ZT
PROVIDER: S-EPMC6983034 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Muhseen Ziyad Tariq ZT Li Guanglin G
Molecules (Basel, Switzerland) 20191230 1
Overexpression of murine double minute 2 (MDM2) results in the inactivation of p53 and causes cancer which is a leading cause of death in recent era. In recent decades, much attention has been paid to discover potential inhibitors against MDM2 in order to cure cancer. Outcomes from studies proposes that the MDM2 is a hot target to screen potent antagonists. Thus, this study aims at discovering natural compounds using several computational approaches to inhibit the MDM2 and to eliminate p53-MDM2 ...[more]