Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
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ABSTRACT:
SUBMITTER: Pokatayev V
PROVIDER: S-EPMC6983345 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Pokatayev Vladislav V Yang Kun K Tu Xintao X Dobbs Nicole N Wu Jianjun J Kalb Robert G RG Yan Nan N
Nature immunology 20200113 2
STING (stimulator of interferon genes) is an important innate immune protein, but its homeostatic regulation at the resting state is unknown. Here, we identified TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation. Tollip deficiency results in reduced STING protein in nonhematopoietic cells and tissues, and renders STING protein unstable in immune cells, leading to severely dampened STING signaling capacity. The competing degradation mechanism of resting-state S ...[more]
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