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A visible-light photoactivatable di-nuclear Pt^IV triazolato azido complex.

ABSTRACT: A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5'-guanosine monophosphate (5'-GMP) produced both PtIV and PtII 5'-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals - particularly hydroxyl radicals - was significantly reduced in the presence of 5'-GMP.

SUBMITTER: Yao K

PROVIDER: S-EPMC6984334 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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A visible-light photoactivatable di-nuclear PtIV triazolato azido complex.

Yao Kezi K Bertran Arnau A Howarth Alison A Goicoechea Jose M JM Hare Samuel M SM Rees Nicholas H NH Foroozandeh Mohammadali M Bowen Alice M AM Farrer Nicola J NJ

Chemical communications (Cambridge, England) 20190901 75

A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5'-guanosine monophosphate (5'-GMP) produced both PtIV and PtII 5'-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals - particularly hydroxyl radicals - w ...[more]

PMID: 31475995

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