Ontology highlight
ABSTRACT:
SUBMITTER: Kottyan LC
PROVIDER: S-EPMC6984394 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kottyan Leah C LC Parameswaran Sreeja S Weirauch Matthew T MT Rothenberg Marc E ME Martin Lisa J LJ
The Journal of allergy and clinical immunology 20200101 1
Eosinophilic esophagitis (EoE) is a chronic allergic disease associated with marked mucosal eosinophil accumulation. Multiple studies have reported a strong familial component to EoE, with the presence of EoE increasing the risk for other family members with EoE. Epidemiologic studies support an important role for environmental risk factors as modulators of genetic risk. In a small percentage of cases, including patients who have Mendelian diseases with co-occurrent EoE, rare genetic variation w ...[more]