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Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.


ABSTRACT: BACKGROUND:We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD. METHODS:This case-control study enrolled 67 patients within the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort at two transplant centers. CAD was defined as a greater than 25% rise in serum creatinine relative to a 3 month post-transplant baseline. Urine samples from patients with and without CAD were analyzed using 16S V4 bacterial ribosomal DNA sequences. RESULTS:Corynebacterium was more prevalent in female and male patients with CAD compared to non-CAD female patients (P = 0.0005). A total 21 distinct Operational Taxonomic Unit (OTUs) were identified as significantly different when comparing CAD and non-CAD patients using Kruskal-Wallis (P < 0.01). A subset analysis of female patients with CAD compared to non-CAD females identified similar differentially abundant OTUs, including the genera Corynebacterium and Staphylococcus (Kruskal-Wallis; P = 0.01; P = 0.004, respectively). Male CAD vs female CAD analysis showed greater abundance of phylum Proteobacteria in males. CONCLUSION:There were differences in the urinary microbiome when comparing female and male CAD patients with their female non-CAD counterparts and these differences persisted in the subset analysis limited to female patients only.

SUBMITTER: Wu JF 

PROVIDER: S-EPMC6984979 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.

Wu Jennifer F JF   Muthusamy Amutha A   Al-Ghalith Gabriel A GA   Knights Dan D   Guo Bin B   Wu Baolin B   Remmel Rory P RP   Schladt David P DP   Alegre Maria-Luisa ML   Oetting William S WS   Jacobson Pamala A PA   Israni Ajay K AK  

Clinical transplantation 20181118 12


<h4>Background</h4>We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD.<h4>Methods</h4>This case-control study enrolled 67 patients within the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort at two transplant centers. CAD was defined as a greater than 25% rise in serum creatinine relative to a 3 month post-transplant basel  ...[more]

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