A comparative study of 5 different antibiotic prophylaxis regimes in 4500 total knee replacements.
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ABSTRACT: Aim
To compare the incidence of surgical site infection with different antibiotic regimes in elective total knee arthroplasty. We hypothesise that a single high dose of Teicoplanin and Gentamicin is as effective as other regimes.Methods
A retrospective study of prospectively collected data on a total of 4500 elective knee replacements over a 9-year period was conducted in a district general hospital. Data were collected on antibiotic regime, patient characteristics, infection (treatment, infective agents, sensitivities) and complications.Results
Five different antibiotic regimes that have been used in elective knee arthroplasty were identified in our institution. 40 patients in total were identified who had a deep infection. Rates of deep surgical site infection were not significantly different between the five groups (p?=?0.83).Conclusion
A single pre-operative dose of Teicoplanin and Gentamicin has similar efficacy of prophylaxis to other regimes for patients undergoing primary elective total knee replacements. We recommend the choice of prophylaxis regimen is made locally based on pathogen virulence, drug resistance and cost.
SUBMITTER: Babu S
PROVIDER: S-EPMC6985026 | biostudies-literature | 2020 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
A comparative study of 5 different antibiotic prophylaxis regimes in 4500 total knee replacements.
Babu Satish S Al-Obaidi Bilal B Jardine Alan A Jonas Sam S Al-Hadithy Nawfal N Satish Venkat V
Journal of clinical orthopaedics and trauma 20181214 1
<h4>Aim</h4>To compare the incidence of surgical site infection with different antibiotic regimes in elective total knee arthroplasty. We hypothesise that a single high dose of Teicoplanin and Gentamicin is as effective as other regimes.<h4>Methods</h4>A retrospective study of prospectively collected data on a total of 4500 elective knee replacements over a 9-year period was conducted in a district general hospital. Data were collected on antibiotic regime, patient characteristics, infection (tr ...[more]
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