Ontology highlight
ABSTRACT:
SUBMITTER: Lerch TF
PROVIDER: S-EPMC6985046 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lerch Thomas F TF Sharpe Penelope P Mayclin Stephen J SJ Edwards Thomas E TE Polleck Sharon S Rouse Jason C JC Zou Qin Q Conlon Hugh D HD
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20200201 1
<h4>Background</h4>Higher-order structure (HOS) assessment is an important component of biosimilarity evaluations. While established spectroscopic methods are routinely used to characterize structure and evaluate similarity, the addition of X-ray crystallographic analysis to these biophysical methods enables orthogonal elucidation of HOS at higher resolution.<h4>Methods</h4>Crystal structures of the infliximab biosimilar PF-06438179/GP1111 and the reference product Remicade<sup>®</sup>, sourced ...[more]