Ontology highlight
ABSTRACT:
SUBMITTER: Abe H
PROVIDER: S-EPMC6985080 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Abe Hideaki H Natsumeda Manabu M Okada Masayasu M Watanabe Jun J Tsukamoto Yoshihiro Y Kanemaru Yu Y Yoshimura Junichi J Oishi Makoto M Hashizume Rintaro R Kakita Akiyoshi A Fujii Yukihiko Y
Frontiers in oncology 20200121
Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack of O6-methyl-guanine-DNA methyltransferase (<i>MGMT</i>) promoter methylation, resulting in increased MGMT expression. We established the NGT16 cell line with <i>HIST1H3B</i> K27M and <i>ACVR1</i> G328E gene mutations from a DMG patient and used this cell line and other ...[more]