Key Transitions in the Evolution of Rapid and Slow Growing Mycobacteria Identified by Comparative Genomics.

ABSTRACT: Mycobacteria have been classified into rapid and slow growing phenotypes, but the genetic factors that underlie these growth rate differences are not well understood. We compared the genomes of 157 mycobacterial species, representing all major branches of the mycobacterial phylogenetic tree to identify genes and operons enriched among rapid and slow growing mycobacteria. Overlaying growth phenotype on a phylogenetic tree based on 304 core genes suggested that ancestral mycobacteria had a rapid growth phenotype with a single major evolutionary separation into rapid and slow growing sub-genera. We identified 293 genes enriched among rapid growing sub-genera, including genes encoding for amino acid transport/metabolism (e.g., livFGMH operon) and transcription, as well as novel ABC tran

SUBMITTER: Bachmann NL 

PROVIDER: S-EPMC6985099 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature