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Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila.

ABSTRACT: Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure and behavior including sleep-activity and negative geotaxis in aged Drosophila. We also assessed the survival rate of flies after hypoxia and/or exercise. One-thousand wild-type w1118 virgin female flies were randomly divided into four groups and treated with NH and/or exercise from ages 3-6 weeks. We found that exercise remarkably delayed the decline of actin and myosin and the age-related changes in cardiac structure, improved abnormal cardiac contraction, and enhanced the cardiac pumping force by inducing cardiac hypertrophy and delaying deterioration of cardiac contractility and diastolic compliance, and improved abnormal heart contraction. NH also increased the content of actin and myosin, but induced a decrease in heart diameter and heart rate, as well as an increase in the number of mitochondria and deeper sleep, which may be the manifestation of energy saving under long-term hypoxia. Both NH and exercise improved sleep quality and climbing ability of aged flies, as well as extended the maximum life span, which shows the benefits of hypoxia and exercise. Finally, the superposition of NH and exercise did not impart any obvious physiological and behavior improvement. Therefore, it is necessary to further explore the appropriate combination of hypoxia and exercise.

SUBMITTER: Li QF

PROVIDER: S-EPMC6985434 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female <i>Drosophila</i>.

Li Qiu Fang QF Wang Hui H Zheng Lan L Yang Fan F Li Han Zhe HZ Li Jin Xiu JX Cheng Dan D Lu Kai K Liu Yang Y

Frontiers in physiology 20200121

Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure and behavior including sleep-activity and negative geotaxis in aged <i>Drosophila.</i> We also assessed the survival rate of flies after hypoxia and/or exercise. One-thousand wild-ty ...[more]

PMID: 32038290

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Project description:BACKGROUND:Few studies have investigated the association between screen viewing (SV) and sleep duration among young children. This study aims to examine the association between total and device-specific SV and sleep duration among children aged 2 and below. METHODS:We conducted a cross-sectional study of 714 Singaporean children aged 2?years and below. Parents were recruited during routine well-child clinic visits from two national polyclinics. In Singapore, all parents visit well-child clinics with their children at regular intervals for routine check-ups and vaccinations. Socio-demographic characteristics, duration of total and device-specific SV, and sleep duration were reported by parents via interviewer-administered questionnaires. Multiple linear regression analysis was used to assess associations between various types of SV and sleep duration, adjusted for socio-demographic variables. Due to significant interaction between SV and age, stratified analyses for children aged less than 6?months and those aged 7-24?months were performed. RESULTS:The prevalence of daily SV among children was 53.1%; 28.3% in children up to 6?months and 73.8% in children aged 7 to 24?months. TV viewing was reported for 44.3% of all children and mobile device SV for 30.1%. Children's average sleep duration was 13.9 (SD?=?3.5) hours daily and younger children had longer sleep duration than older ones (up to 6?months: mean?=?15.6?h, SD?=?3.9; 7-24?months: mean?=?12.4?h, SD?=?2.2; P?<?0.01). In the regression analysis among all children, each 1?h per day increment in total SV was significantly associated with 0.26?h shorter sleep duration with similar significant associations for TV (??=?-?0.28?h, 95%CI: -0.50, -?0.06) and mobile devices (??=?-?0.35?h, 95%CI: -0.61, -?0.09). Stratified analysis revealed significantly greater reductions in sleep with higher SV among children aged 6?months and below (??=?-?0.73?h, 95%CI: -1.12, -?0.34), while associations were weaker in older children (??=?-?0.13?h, 95% CI: -0.24, -?0.01). CONCLUSIONS:This study provides evidence for a substantial association between longer SV and shorter sleep duration among very young children. These associations appeared stronger among children aged 6?months and below as compared with those aged 7 to 24?months. Further studies are warranted to confirm our findings.

Dataset Information

Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila.

Publications

Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female <i>Drosophila</i>.

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