Ontology highlight
ABSTRACT:
SUBMITTER: Schukken KM
PROVIDER: S-EPMC6985455 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Life science alliance 20200124 2
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that are aneuploid or exhibit a CIN phenotype. We find that aneuploid cells are much more sensitive to the energy metabolism regulating drug ZLN005 than their euploid counterparts. Furthermore, cells with an ...[more]