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Simultaneous Infection with Enterobacteriaceae and Pseudomonas aeruginosa Harboring Multiple Carbapenemases in a Returning Traveler Colonized with Candida auris.

ABSTRACT: We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.

SUBMITTER: Khan A 

PROVIDER: S-EPMC6985746 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Simultaneous Infection with <i>Enterobacteriaceae</i> and Pseudomonas aeruginosa Harboring Multiple Carbapenemases in a Returning Traveler Colonized with Candida auris.

Khan Ayesha A   Shropshire William C WC   Hanson Blake B   Dinh An Q AQ   Wanger Audrey A   Ostrosky-Zeichner Luis L   Arias Cesar A CA   Miller William R WR  

Antimicrobial agents and chemotherapy 20200127 2

We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i> in a 56-year-old woman who received health care in India and was also colonized by <i>Candida auris</i> A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility  ...[more]

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