Ontology highlight
ABSTRACT:
SUBMITTER: Melgar K
PROVIDER: S-EPMC6985905 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Melgar Katelyn K Walker Morgan M MM Jones LaQuita M LM Bolanos Lyndsey C LC Hueneman Kathleen K Wunderlich Mark M Jiang Jian-Kang JK Wilson Kelli M KM Zhang Xiaohu X Sutter Patrick P Wang Amy A Xu Xin X Choi Kwangmin K Tawa Gregory G Lorimer Donald D Abendroth Jan J O'Brien Eric E Hoyt Scott B SB Berman Ellin E Famulare Christopher A CA Mulloy James C JC Levine Ross L RL Perentesis John P JP Thomas Craig J CJ Starczynowski Daniel T DT
Science translational medicine 20190901 508
Targeted inhibitors to oncogenic kinases demonstrate encouraging clinical responses early in the treatment course; however, most patients will relapse because of target-dependent mechanisms that mitigate enzyme-inhibitor binding or through target-independent mechanisms, such as alternate activation of survival and proliferation pathways, known as adaptive resistance. Here, we describe mechanisms of adaptive resistance in FMS-like receptor tyrosine kinase (FLT3)-mutant acute myeloid leukemia (AML ...[more]