Ontology highlight
ABSTRACT:
SUBMITTER: Delle Bovi RJ
PROVIDER: S-EPMC6985913 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Delle Bovi Richard J RJ Kim JiHyun J Suresh Pavana P London Erwin E Miller W Todd WT
Biochimica et biophysica acta. Biomembranes 20190122 4
The plasma membrane is a dynamic environment with a complex composition of lipids, proteins, and cholesterol. Areas enriched in cholesterol and sphingolipids are believed to form lipid rafts, domains of highly ordered lipids. The unique physical properties of these domains have been proposed to influence many cellular processes. Here, we demonstrate that the activation of insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) depends critically on the structures of membrane ster ...[more]