Ontology highlight
ABSTRACT:
SUBMITTER: Majumder M
PROVIDER: S-EPMC6986764 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Majumder Mrinmoyee M Palanisamy Viswanathan V
PLoS genetics 20200115 1
RNA-binding proteins (RBPs) associate with the primary, precursor, and mature microRNAs, which in turn control post-transcriptional gene regulation. Here, by small RNAseq, we show that RBP FXR1 controls the expression of a subset of mature miRNAs, including highly expressed miR301a-3p in oral cancer cells. We also confirm that FXR1 controls the stability of miR301a-3p. Exoribonuclease PNPT1 degrades miR301a-3p in the absence of FXR1 in oral cancer cells, and the degradation is rescued in the FXR ...[more]