Cannabinoid exposure and altered DNA methylation in rat and human sperm.
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ABSTRACT:
SUBMITTER: Murphy SK
PROVIDER: S-EPMC6986792 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Cannabinoid exposure and altered DNA methylation in rat and human sperm.
Murphy Susan K SK Itchon-Ramos Nilda N Visco Zachary Z Huang Zhiqing Z Grenier Carole C Schrott Rose R Acharya Kelly K Boudreau Marie-Helene MH Price Thomas M TM Raburn Douglas J DJ Corcoran David L DL Lucas Joseph E JE Mitchell John T JT McClernon F Joseph FJ Cauley Marty M Hall Brandon J BJ Levin Edward D ED Kollins Scott H SH
Epigenetics 20181218 12
Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Pathway analyses indicated Hippo Signaling and Pathways in Cancer as enriched with altered genes (Bonferr ...[more]
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