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Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.

ABSTRACT: 22q11.2 deletion syndrome (22q11DS)-a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22-is associated with an elevated risk of psychosis and other developmental brain disorders. Prior single-site diffusion magnetic resonance imaging (dMRI) studies have reported altered white matter (WM) microstructure in 22q11DS, but small samples and variable methods have led to contradictory results. Here we present the largest study ever conducted of dMRI-derived measures of WM microstructure in 22q11DS (334 22q11.2 deletion carriers and 260 healthy age- and sex-matched controls; age range 6-52 years). Using harmonization protocols developed by the ENIGMA-DTI working group, we identified widespread reductions in mean, axial and radial diffusivities in 22q11DS, most pronounced in regions with major cortico-cortical and cortico-thalamic fibers: the corona radiata, corpus callosum, superior longitudinal fasciculus, posterior thalamic radiations, and sagittal stratum (Cohen's d's ranging from -0.9 to -1.3). Only the posterior limb of the internal capsule (IC), comprised primarily of corticofugal fibers, showed higher axial diffusivity in 22q11DS. 22q11DS patients showed higher mean fractional anisotropy (FA) in callosal and projection fibers (IC and corona radiata) relative to controls, but lower FA than controls in regions with predominantly association fibers. Psychotic illness in 22q11DS was associated with more substantial diffusivity reductions in multiple regions. Overall, these findings indicate large effects of the 22q11.2 deletion on WM microstructure, especially in major cortico-cortical connections. Taken together with findings from animal models, this pattern of abnormalities may reflect disrupted neurogenesis of projection neurons in outer cortical layers.

SUBMITTER: Villalon-Reina JE

PROVIDER: S-EPMC6986984 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.

Villalón-Reina Julio E JE Martínez Kenia K Qu Xiaoping X Ching Christopher R K CRK Nir Talia M TM Kothapalli Deydeep D Corbin Conor C Sun Daqiang D Lin Amy A Forsyth Jennifer K JK Kushan Leila L Vajdi Ariana A Jalbrzikowski Maria M Hansen Laura L Jonas Rachel K RK van Amelsvoort Therese T Bakker Geor G Kates Wendy R WR Antshel Kevin M KM Fremont Wanda W Campbell Linda E LE McCabe Kathryn L KL Daly Eileen E Gudbrandsen Maria M Murphy Clodagh M CM Murphy Declan D Craig Michael M Emanuel Beverly B McDonald-McGinn Donna M DM Vorstman Jacob A S JAS Fiksinski Ania M AM Koops Sanne S Ruparel Kosha K Roalf David D Gur Raquel E RE Eric Schmitt J J Simon Tony J TJ Goodrich-Hunsaker Naomi J NJ Durdle Courtney A CA Doherty Joanne L JL Cunningham Adam C AC van den Bree Marianne M Linden David E J DEJ Owen Michael M Moss Hayley H Kelly Sinead S Donohoe Gary G Murphy Kieran C KC Arango Celso C Jahanshad Neda N Thompson Paul M PM Bearden Carrie E CE

Molecular psychiatry 20190729 11

22q11.2 deletion syndrome (22q11DS)-a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22-is associated with an elevated risk of psychosis and other developmental brain disorders. Prior single-site diffusion magnetic resonance imaging (dMRI) studies have reported altered white matter (WM) microstructure in 22q11DS, but small samples and variable methods have led to contradictory results. Here we present the largest study ever conducted of dMRI-derived measures of WM mic ...[more]

PMID: 31358905

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Project description:Children and adolescents with congenital heart disease (CHD) are at risk for mild to moderate cognitive impairments. In particular, impaired working memory performance has been found in CHD patients of all ages. Working memory is an important domain of higher order cognitive function and is crucial for everyday activities, with emerging importance in adolescence. However, the underlying neural correlate of working memory impairments in CHD is not yet fully understood. Diffusion tensor imaging and tract based spatial statistics analyses were conducted in 47 adolescent survivors of childhood cardiopulmonary bypass surgery (24 females) and in 44 healthy controls (24 females) between 11 and 16 years of age (mean age = 13.9, SD = 1.6). Fractional anisotropy (FA) of white matter diffusion was compared between groups and was correlated with working memory performance, derived from the Wechsler Intelligence Scale for Children-IV. CHD patients had significantly poorer working memory compared to controls (p = 0.001). Widespread bilateral reduction in FA was observed in CHD patients compared to healthy controls (threshold-free cluster enhancement (TFCE) corrected p < 0.05). This reduction in FA was present both in cyanotic and acyanotic CHD patients compared to healthy controls (both p < 0.001). The FA reduction in the frontal lobe, mainly in the forceps minor, was associated with poorer working memory performance in both patients with CHD and healthy controls (TFCE corrected p < 0.05). The current findings underline that in CHD patients, irrespective of disease severity, disrupted or delayed maturation of white matter may persist into adolescence and is associated with working memory impairments, particularly if present in the frontal lobe. Adolescence, which is a crucial period for prefrontal brain maturation, may offer a window of opportunity for intervention in order to support the maturation of frontal brain regions and therefore improve higher order cognitive function in patients with CHD.

Dataset Information

Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.

Publications

Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.

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