Intrinsic mitotic activity supports the human salivary gland acinar cell population.
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ABSTRACT:
SUBMITTER: Ingalls MH
PROVIDER: S-EPMC6987008 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Intrinsic mitotic activity supports the human salivary gland acinar cell population.
Ingalls Matthew H MH Hollomon Andrew J AJ Newlands Shawn D SD McDavid Andrew N AN Ovitt Catherine E CE
FEBS letters 20191002 2
To develop treatments for salivary gland dysfunction, it is important to understand how human salivary glands are maintained under normal homeostasis. Previous data from our lab demonstrated that murine salivary acinar cells maintain the acinar cell population through self-duplication under conditions of homeostasis, as well as after injury. Early studies suggested that human acinar cells are mitotically active, but the identity of the resultant daughter cells was not clear. Using markers of cel ...[more]
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