Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice.
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ABSTRACT:
SUBMITTER: Bachta KER
PROVIDER: S-EPMC6987207 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Systemic infection facilitates transmission of Pseudomonas aeruginosa in mice.
Bachta Kelly E R KER Allen Jonathan P JP Cheung Bettina H BH Chiu Cheng-Hsun CH Hauser Alan R AR
Nature communications 20200128 1
Health care-associated infections such as Pseudomonas aeruginosa bacteremia pose a major clinical risk for hospitalized patients. However, these systemic infections are presumed to be a "dead-end" for P. aeruginosa and to have no impact on transmission. Here, we use a mouse infection model to show that P. aeruginosa can spread from the bloodstream to the gallbladder, where it replicates to extremely high numbers. Bacteria in the gallbladder can then seed the intestines and feces, leading to tran ...[more]
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