Ontology highlight
ABSTRACT:
SUBMITTER: Veyel D
PROVIDER: S-EPMC6987209 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Veyel Daniel D Wenger Kathrin K Broermann Andre A Bretschneider Tom T Luippold Andreas H AH Krawczyk Bartlomiej B Rist Wolfgang W Simon Eric E
Scientific reports 20200128 1
Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be useful for drug development. Here we present a multi-omics approach to characterize the molecular pathophysiology and to identify new plasma biomarkers in a choline-deficient L-amino acid-defined diet ...[more]