Immunotherapy Targeting Neurodegenerative Proteinopathies: ?-Synucleinopathies and Tauopathies.
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ABSTRACT:
SUBMITTER: Shin J
PROVIDER: S-EPMC6987523 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies.
Shin Junghwan J Kim Han-Joon HJ Jeon Beomseok B
Journal of movement disorders 20191219 1
α-Synuclein and tau deposition in the central nervous system is responsible for various parkinsonian syndromes, including Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. Emerging evidence has suggested that pathologic α-synuclein and tau are transmitted from cell to cell and further accelerate the aggregation of pathologic proteins in neighboring cells. Furthermore, extracellular pathologic proteins have also ...[more]
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