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The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population.

ABSTRACT: PURPOSE:Genetic variants play a critical role in the development of breast cancer. This investigation aimed to explore the association between CASC16 polymorphisms and breast cancer susceptibility. METHODS:We conducted a case-control study of 681 patients and 680 healthy individuals to investigate the correlation of five SNPs with breast cancer in a Northwest Chinese female population. Odds ratios (OR) and 95% confidence intervals (CIs) were used to assess the association. RESULTS:Our study found that rs4784227 and rs12922061 were significantly related to an increased susceptibility to breast cancer (OR 1.22, p =?0.022; OR 1.21, p =?0.026). While rs3803662 was a protective role in breast cancer risk (OR 0.69, p =?0.042). Stratified analyses indicated that rs4784227 and rs12922061 would increase breast cancer susceptibility at age?>? 50?years. Rs3803662 was a reduced factor of breast cancer risk by age???50?years. Rs4784227 was significantly increased risk of breast cancer in stage III/IV. The rs45544231 and rs3112612 had a protective effect on breast cancer with tumor size >?2?cm. Rs4784227 and rs12922061 could enhance breast cancer risk in lymph node metastasis positive individuals. CASC16 rs12922061 and rs4784227 polymorphisms correlated with an increased risk of breast cancer in BMI?>? 24?kg/m2. Haplotype analyses revealed that Grs45544231 Trs12922061 Ars3112612 and Grs45544231 Crs12922061 Ars3112612 haplotypes decreased breast cancer risk. CONCLUSION:Our study revealed that CASC16 genetic variants were significantly related to breast cancer susceptibility, which might give scientific evidence for exploring the molecular mechanism of breast cancer.

SUBMITTER: Zuo X

PROVIDER: S-EPMC6988193 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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