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ABSTRACT:
SUBMITTER: Tokairin Y
PROVIDER: S-EPMC6988766 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
ChemistryOpen 20200129 1
Four differently substituted chiral Ni(II)-complexes of dehydroalanine Schiff base were prepared and reacted with BrCF<sub>2</sub>COOEt/Cu under the standard reaction conditions. The observed diastereoselectivity was found to depend on the degree and pattern of chlorine substitution for hydrogen in the structure of the dehydroalanine complexes. The unsubstituted complex gave the ratio of diastereomers (<i>S</i>)(2<i>S</i>)/(<i>S</i>)(2<i>R</i>) of 66/34. On the other hand, introduction of chlori ...[more]