Drosophila strain specific response to cisplatin neurotoxicity.
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ABSTRACT:
SUBMITTER: Groen CM
PROVIDER: S-EPMC6988872 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Drosophila strain specific response to cisplatin neurotoxicity.
Groen Christopher M CM Podratz Jewel L JL Treb Kevin K Windebank Anthony J AJ
Fly 20180101 3-4
Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic ba ...[more]
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