Dataset Information

The age-specific burden and household and school-based predictors of child and adolescent tuberculosis infection in rural Uganda.

ABSTRACT: Background: The age-specific epidemiology of child and adolescent tuberculosis (TB) is poorly understood, especially in rural areas of East Africa. We sought to characterize the age-specific prevalence and predictors of TB infection among children and adolescents living in rural Uganda, and to explore the contribution of household TB exposure on TB infection.

Methods: From 2015-2016 we placed and read 3,121 tuberculin skin tests (TST) in children (5-11 years old) and adolescents (12-19 years old) participating in a nested household survey in 9 rural Eastern Ugandan communities. TB infection was defined as a positive TST (induration ?10mm or ?5mm if living with HIV). Age-specific prevalence was estimated using inverse probability weighting to adjust for incomplete measurement. Generalized estimating equations were used to assess the association between TB infection and multi-level predictors.

Results: The adjusted prevalence of TB infection was 8.5% (95%CI: 6.9-10.4) in children and 16.7% (95% CI:14.0-19.7) in adolescents. Nine percent of children and adolescents with a prevalent TB infection had a household TB contact. Among children, having a household TB contact was strongly associated with TB infection (aOR 5.5, 95% CI: 1.7-16.9), but the strength of this association declined among adolescents and did not meet significance (aOR 2.3, 95% CI: 0.8-7.0). The population attributable faction of TB infection due to a household TB contact was 8% for children and 4% among adolescents. Mobile children and adolescents who travel outside of their community for school had a 1.7 (95% CI 1.0-2.9) fold higher odds of TB infection than those who attended school in the community.

Conclusion: Children and adolescents in this area of rural eastern Uganda suffer a significant burden of TB. The majority of TB infections are not explained by a known household TB contact. Our findings underscore the need for community-based TB prevention interventions, especially among mobile youth.

SUBMITTER: Marquez C

PROVIDER: S-EPMC6988961 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The age-specific burden and household and school-based predictors of child and adolescent tuberculosis infection in rural Uganda.

Marquez Carina C Atukunda Mucunguzi M Balzer Laura B LB Chamie Gabriel G Kironde Joel J Ssemmondo Emmanuel E Ruel Theodore D TD Mwangwa Florence F Tram Khai Hoan KH Clark Tamara D TD Kwarisiima Dalsone D Petersen Maya M Kamya Moses R MR Charlebois Edwin D ED Havlir Diane V DV

PloS one 20200129 1

<h4>Background</h4>The age-specific epidemiology of child and adolescent tuberculosis (TB) is poorly understood, especially in rural areas of East Africa. We sought to characterize the age-specific prevalence and predictors of TB infection among children and adolescents living in rural Uganda, and to explore the contribution of household TB exposure on TB infection.<h4>Methods</h4>From 2015-2016 we placed and read 3,121 tuberculin skin tests (TST) in children (5-11 years old) and adolescents (12 ...[more]

PMID: 31995631

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Dataset Information

The age-specific burden and household and school-based predictors of child and adolescent tuberculosis infection in rural Uganda.

Publications

The age-specific burden and household and school-based predictors of child and adolescent tuberculosis infection in rural Uganda.

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