Ontology highlight
ABSTRACT:
SUBMITTER: Park D
PROVIDER: S-EPMC6989216 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Park Danielle D Wershof Esther E Boeing Stefan S Labernadie Anna A Jenkins Robert P RP George Samantha S Trepat Xavier X Bates Paul A PA Sahai Erik E
Nature materials 20191028 2
The isotropic or anisotropic organization of biological extracellular matrices has important consequences for tissue function. We study emergent anisotropy using fibroblasts that generate varying degrees of matrix alignment from uniform starting conditions. This reveals that the early migratory paths of fibroblasts are correlated with subsequent matrix organization. Combined experimentation and adaptation of Vicsek modelling demonstrates that the reorientation of cells relative to each other fol ...[more]