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Constraint and trade-offs regulate energy expenditure during childhood.


ABSTRACT: Children's metabolic energy expenditure is central to evolutionary and epidemiological frameworks for understanding variation in human phenotype and health. Nonetheless, the impact of a physically active lifestyle and heavy burden of infectious disease on child metabolism remains unclear. Using energetic, activity, and biomarker measures, we show that Shuar forager-horticulturalist children of Amazonian Ecuador are ~25% more physically active and, in association with immune activity, have ~20% greater resting energy expenditure than children from industrial populations. Despite these differences, Shuar children's total daily energy expenditure, measured using doubly labeled water, is indistinguishable from industrialized counterparts. Trade-offs in energy allocation between competing physiological tasks, within a constrained energy budget, appear to shape childhood phenotypic variation (e.g., patterns of growth). These trade-offs may contribute to the lifetime obesity and metabolic health disparities that emerge during rapid economic development.

SUBMITTER: Urlacher SS 

PROVIDER: S-EPMC6989306 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Constraint and trade-offs regulate energy expenditure during childhood.

Urlacher Samuel S SS   Snodgrass J Josh JJ   Dugas Lara R LR   Sugiyama Lawrence S LS   Liebert Melissa A MA   Joyce Cara J CJ   Pontzer Herman H  

Science advances 20191218 12


Children's metabolic energy expenditure is central to evolutionary and epidemiological frameworks for understanding variation in human phenotype and health. Nonetheless, the impact of a physically active lifestyle and heavy burden of infectious disease on child metabolism remains unclear. Using energetic, activity, and biomarker measures, we show that Shuar forager-horticulturalist children of Amazonian Ecuador are ~25% more physically active and, in association with immune activity, have ~20% g  ...[more]

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