Ontology highlight
ABSTRACT:
SUBMITTER: Cao X
PROVIDER: S-EPMC6989492 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200129 1
Hypoxia in solid tumors is thought to be an important factor in resistance to therapy, but the extreme microscopic heterogeneity of the partial pressures of oxygen (pO<sub>2</sub>) between the capillaries makes it difficult to characterize the scope of this phenomenon without invasive sampling of oxygen distributions throughout the tissue. Here we develop a non-invasive method to track spatial oxygen distributions in tumors during fractionated radiotherapy, using oxygen-dependent quenching of ph ...[more]