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Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.


ABSTRACT: Gliomas are infiltrative brain tumors with a margin difficult to identify. 5-ALA induced PpIX fluorescence measurements are a clinical standard, but expert-based classification models still lack sensitivity and specificity. Here a fully automatic clustering method is proposed to discriminate glioma margin. This is obtained from spectroscopic fluorescent measurements acquired with a recently introduced intraoperative set up. We describe a data-driven selection of best spectral features and show how this improves results of margin prediction from healthy tissue by comparison with the standard biomarker-based prediction. This pilot study based on 10 patients and 50 samples shows promising results with a best performance of 77% of accuracy in healthy tissue prediction from margin tissue.

SUBMITTER: Leclerc P 

PROVIDER: S-EPMC6989497 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.

Leclerc Pierre P   Ray Cedric C   Mahieu-Williame Laurent L   Alston Laure L   Frindel Carole C   Brevet Pierre-François PF   Meyronet David D   Guyotat Jacques J   Montcel Bruno B   Rousseau David D  

Scientific reports 20200129 1


Gliomas are infiltrative brain tumors with a margin difficult to identify. 5-ALA induced PpIX fluorescence measurements are a clinical standard, but expert-based classification models still lack sensitivity and specificity. Here a fully automatic clustering method is proposed to discriminate glioma margin. This is obtained from spectroscopic fluorescent measurements acquired with a recently introduced intraoperative set up. We describe a data-driven selection of best spectral features and show h  ...[more]

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