Ontology highlight
ABSTRACT:
SUBMITTER: Gothlin Eremo A
PROVIDER: S-EPMC6989629 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Göthlin Eremo Anna A Lagergren Kajsa K Othman Lana L Montgomery Scott S Andersson Göran G Tina Elisabet E
Scientific reports 20200129 1
Breast cancer patients treated with tamoxifen may experience recurrence due to endocrine resistance, which highlights the need for additional predictive and prognostic biomarkers. The glyco-phosphoprotein osteopontin (OPN), encoded by the SPP1 gene, has previously shown to be associated with poor prognosis in breast cancer. However, studies on the predictive value of OPN are inconclusive. In the present study, we evaluated tissue SPP1 mRNA and OPN protein expression as markers of recurrence in e ...[more]