Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes.
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ABSTRACT:
SUBMITTER: Berg MEA
PROVIDER: S-EPMC6990439 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes.
Berg Mika E A MEA Naams Jette-Britt JB Hautala Laura C LC Tolvanen Tuomas A TA Ahonen Jari P JP Lehtonen Sanna S Wähälä Kristiina K
ACS omega 20200114 3
A series of substituted sulfonanilide analogs were prepared and evaluated as novel potent inhibitors of SH2 domain-containing inositol polyphosphate 5'-phosphatase 2 (SHIP2). SHIP2 has been shown to be a new attractive target for the treatment of insulin resistance in type 2 diabetes mellitus (T2D), which can lead to life-threatening diabetic kidney disease (DKD). Amongst the synthesized compounds, the two most promising candidates, <b>10</b> and <b>11</b>, inhibited SHIP2 significantly. Additio ...[more]
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