Ontology highlight
ABSTRACT:
SUBMITTER: Fanelli GN
PROVIDER: S-EPMC6990491 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Fanelli Giuseppe Nicolò GN Dal Pozzo Carlo Alberto CA Depetris Ilaria I Schirripa Marta M Brignola Stefano S Biason Paola P Balistreri Mariangela M Dal Santo Luca L Lonardi Sara S Munari Giada G Loupakis Fotios F Fassan Matteo M
Cancer cell international 20200129
Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8-15% of CRCs harbor a mutation in <i>BRAF</i> gene, a proto-oncogene involved in cell proliferation, differentiation and survival through the MAPK signaling cascade. The acquisition of <i>BRAF</i> mutation is an early event in the "serrated" CRC carcinogenetic pathway and is associated with specific and aggressive clinico-pathological a ...[more]