Association between metabolic syndrome and prognosis of breast cancer: a meta-analysis of follow-up studies.

ABSTRACT: Background:Metabolic syndrome (MetS) has been suggested to be a risk factor for many cancers, including breast cancer. However, it remains unclear whether MetS predicts poor prognosis in women with breast cancer. A meta-analysis was performed to summarize the association between MetS and clinical outcome in women with breast cancer. Methods:Cohort studies were identified by search of PubMed and Embase databases. A random-effect model incorporating the potential heterogeneity was applied to pool the results. Subgroup analyses according to the ethnicity and study design were performed. Results:Nine cohort studies with 17,892 women with breast cancer were included. Pooled results showed that MetS was significantly associated with an increased risk of breast cancer recurrence (adjusted risk ratio [RR]?=?1.52, 95%, p?=?0.02). Subgroup analyses showed that MetS was independently associated with increased recurrence of breast cancer in Caucasians (adjusted RR?=?1.75, p?=?0.02), but not in Asians (adjusted RR?=?1.07, p?=?0.81), and MetS was associated with a trend of increased risk of breast cancer recurrence in both the prospective and retrospective studies. Although we failed to show a significant association between MetS and breast cancer related deaths (adjusted RR?=?1.24, p?=?0.41), MetS was associated with increased risk of all-cause deaths in these patients (adjusted RR?=?1.80, p?

SUBMITTER: Li P 

PROVIDER: S-EPMC6990514 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature