Ontology highlight
ABSTRACT:
SUBMITTER: Feuillatre O
PROVIDER: S-EPMC6990629 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Feuillâtre Ofelia O Gély Camille C Huvelle Steve S Baltus Christine B CB Juen Ludovic L Joubert Nicolas N Desgranges Audrey A Viaud-Massuard Marie-Claude MC Martin Camille C
ACS omega 20200117 3
Antibody-drug conjugates (ADCs) are the spearhead of targeted therapies. According to the technology used, the conjugation of a cytotoxic drug to an antibody can produce suboptimal heterogeneous species, impacting the overall efficacy. Herein, we describe the synthesis of HER2-targeting ADCs with three disulfide rebridging heads, allowing homogeneous and site-specific bioconjugation: dibromomaleimide (DBM), dithiomaleimide (DTM), and hybrid thio-bromomaleimide (TBM) chemical bricks to combine th ...[more]