Dataset Information

Plasma Galectin-3 and urine proteomics predict FEV₁ improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.

ABSTRACT:

Background

Patients with severe allergic asthma (SAA) when treated with omalizumab may exhibit different extent of response. Identifying biomarkers that can predict the extent of treatment effectiveness in patients can be useful in personalizing omalizumab treatment.

Methods

Patients from the longitudinal phase of the PROXIMA study were selected for this ancillary study. After 12 months of omalizumab treatment, patients were categorized according to their response to treatment as: "clinical responder" (Asthma Control Questionnaire [ACQ] total score <1 at Month 12 and/or with a reduction in number of exacerbation versus the previous year); "functional responder" (an increment of ≥0.1 L in forced expiratory volume in 1 s [FEV₁] at Month 12 versus baseline); and "super responder" (among clinical responders group, who also showed a functional response). Plasma galectin-3 (GAL-3) levels were quantified using a micro titer plate-based enzyme linked immunosorbent assay kit.

Results

The Majority of patients (86.36%) in sub-study population were identified as clinical responders. Of the total patients identified as clinical responders, 64.86% were identified as super responders. A statistically significant difference in the baseline plasma GAL-3 levels between responders and non-responders was observed only in the functional responders group (P = 0.0446). Patients with plasma GAL-3 level of ≥11 ng/mL had a greater probability of being a super responder (P = 0.0118) or a functional responder (P = 0.0032).

Conclusion

Our findings support the use of plasma GAL-3 as a predictive marker to stratify responders and identify super responders and functional responders to omalizumab treatment in patients with severe allergic asthma using less invasive sample like plasma.

SUBMITTER: Riccio AM

PROVIDER: S-EPMC6992845 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Plasma Galectin-3 and urine proteomics predict FEV<sub>1</sub> improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.

Riccio Anna Maria AM Mauri Pierluigi P De Ferrari Laura L Rossi Rossana R Di Silvestre Dario D Bartezaghi Marta M Saccheri Fabiana F Canonica Giorgio Walter GW

The World Allergy Organization journal 20200124 1

<h4>Background</h4>Patients with severe allergic asthma (SAA) when treated with omalizumab may exhibit different extent of response. Identifying biomarkers that can predict the extent of treatment effectiveness in patients can be useful in personalizing omalizumab treatment.<h4>Methods</h4>Patients from the longitudinal phase of the PROXIMA study were selected for this ancillary study. After 12 months of omalizumab treatment, patients were categorized according to their response to treatment as: ...[more]

PMID: 32015785

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Dataset Information

Plasma Galectin-3 and urine proteomics predict FEV₁ improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.

Background

Methods

Results

Conclusion

Publications

Plasma Galectin-3 and urine proteomics predict FEV<sub>1</sub> improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Plasma Galectin-3 and urine proteomics predict FEV1 improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.

Background

Methods

Results

Conclusion

Publications

Plasma Galectin-3 and urine proteomics predict FEV<sub>1</sub> improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Plasma Galectin-3 and urine proteomics predict FEV₁ improvement in omalizumab-treated patients with severe allergic asthma: Results from the PROXIMA sub-study.