Ontology highlight
ABSTRACT:
SUBMITTER: Huang L
PROVIDER: S-EPMC6993117 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Huang Lu L Ye Kaixiong K McGee Michael C MC Nidetz Natalie F NF Elmore Jessica P JP Limper Candice B CB Southard Teresa L TL Russell David G DG August Avery A Huang Weishan W
Frontiers in immunology 20200124
Interleukin-2 (IL-2) inducible T-cell kinase (ITK) is a non-receptor tyrosine kinase highly expressed in T-cell lineages and regulates multiple aspects of T-cell development and function, mainly through its function downstream of the T-cell receptor. <i>Itk</i> deficiency can lead to CD4 lymphopenia and Epstein-Bar virus (EBV)-associated lymphoproliferation and recurrent pulmonary infections in humans. However, the role of the ITK signaling pathway in pulmonary responses in active tuberculosis d ...[more]