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ABSTRACT: Objective
To verify whether aging can modify the clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS).Material and methods
This observational cross-sectional study was conducted at the reproductive endocrinology clinics of Julio Muller University Hospital and Tropical Institute of Reproductive Medicine in Cuiabá, MT, Brazil, between 2003 and 2017. Both, 796 PCOS and 444 non-PCOS normal cycling women underwent the same examination. PCOS was diagnosed using the Rotterdam criteria as recommended for adolescent and adult subjects. Anthropometric, metabolic, and endocrinological modifications with aging were initially examined in the two groups: control and PCOS. Further analyses were performed after a 5-year age stratification of data throughout the reproductive period. All participants signed a consent form approved by the local ethical committee.Results
Biomarkers of adiposity were more remarkable in African descendant PCOS women. Body weight, waist/hip ratio, fat mass, and BMI were higher in PCOS women and tended to increase at all 5 age-strata, between ?19 and 35 years of age. Serum androgen levels decreased with aging, markedly in PCOS subjects (P < 0.01 for all age-strata comparisons), but remained elevated when compared with the levels found in controls. Carbohydrate markers, triglycerides, and total cholesterol tended to increase over time in PCOS (P < 0.01 for all age-strata comparisons). Total cholesterol also tended to increase with age in non-PCOS women (P = 0.041).Conclusion
The present study has shown that the advancing age influences many features of PCOS women. Biochemical hyperandrogenism, the core criterion recommended in the current systems to define the syndrome, showed statistically significant tendencies to decrease with aging progression but did not normalize. The use of age-adjusted features for the diagnosis of PCOS are recommended.
SUBMITTER: de Medeiros SF
PROVIDER: S-EPMC6993261 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
de Medeiros Sebastião Freitas SF Yamamoto Márcia Marly Winck MMW Souto de Medeiros Matheus Antônio MA Barbosa Bruna Barcelo BB Soares José Maria JM Baracat Edmund Chada EC
Endocrine connections 20200201 2
<h4>Objective</h4>To verify whether aging can modify the clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS).<h4>Material and methods</h4>This observational cross-sectional study was conducted at the reproductive endocrinology clinics of Julio Muller University Hospital and Tropical Institute of Reproductive Medicine in Cuiabá, MT, Brazil, between 2003 and 2017. Both, 796 PCOS and 444 non-PCOS normal cycling women underwent the same examination. PCOS was diagn ...[more]