Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population.

ABSTRACT: BACKGROUND:Vitamin D receptor (VDR) is involved in multiple immune-mediated disorders including oral lichen planus (OLP). This study investigated the association between VDR gene polymorphisms and the risk of OLP. METHODS:In total, 177 OLP patients and 207 healthy participants were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) in the VDR gene were selected and genotyped. RESULTS:The results showed that OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted Odd ratio(OR)?=?2.68, 95% Confidence interval(CI)?=?1.28-5.62, P?=?0.009) and rs7975232 CC genotype (Recessive model: adjusted OR?=?2.25, 95% CI?=?1.10-4.58, P?=?0.026). Moreover, rs2239185 and rs7975232 (P?< 0.01) showed significant cumulative effects on OLP risk.Haplotype analysis showed that the CC haplotype (rs2239185-rs7975232) was associated with an increased risk of OLP (OR?=?3.11, 95% CI?=?1.42-6.83, P?=?0.005), compared with the AC haplotype. CONCLUSION:The rs2239185 and rs7975232 variants of VDR may influence OLP susceptibility, and VDR gene polymorphisms may be candidate susceptibility regions for OLP in a Chinese Han population.

SUBMITTER: Shen H 

PROVIDER: S-EPMC6993400 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature