Ontology highlight
ABSTRACT:
SUBMITTER: Arnold B
PROVIDER: S-EPMC6993868 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Arnold Brian B Sohail Mashaal M Wadsworth Crista C Corander Jukka J Hanage William P WP Sunyaev Shamil S Grad Yonatan H YH
Molecular biology and evolution 20200201 2
Identifying genetic variation in bacteria that has been shaped by ecological differences remains an important challenge. For recombining bacteria, the sign and strength of linkage provide a unique lens into ongoing selection. We show that derived alleles <300 bp apart in Neisseria gonorrhoeae exhibit more coupling linkage than repulsion linkage, a pattern that cannot be explained by limited recombination or neutrality as these couplings are significantly stronger for nonsynonymous alleles than s ...[more]