Ontology highlight
ABSTRACT:
SUBMITTER: Scott NA
PROVIDER: S-EPMC6993871 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
The Biochemical journal 20200101 2
Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded in response to increased sterol levels, whilst others remain stable. We hypothesised that an enzyme at a key branch point in the pathway, lanosterol 14α-demethylase (LDM) may be post-translationally regulated. Here, we show that the preceding enzyme ...[more]