Ontology highlight
ABSTRACT:
SUBMITTER: Sankaran JS
PROVIDER: S-EPMC6993926 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sankaran Jeyantt S JS Sen Buer B Dudakovic Amel A Paradise Christopher R CR Perdue Tony T Xie Zhihui Z McGrath Cody C Styner Maya M Newberg Joshua J Uzer Gunes G van Wijnen Andre J AJ Rubin Janet J
Stem cells (Dayton, Ohio) 20191106 1
Nuclear actin plays a critical role in mediating mesenchymal stem cell (MSC) fate commitment. In marrow-derived MSCs, the principal diaphanous-related formin Diaph3 (mDia2) is present in the nucleus and regulates intranuclear actin polymerization, whereas Diaph1 (mDia1) is localized to the cytoplasm and controls cytoplasmic actin polymerization. We here show that mDia2 can be used as a tool to query actin-lamin nucleoskeletal structure. Silencing mDia2 affected the nucleoskeletal lamin scaffold, ...[more]