Ontology highlight
ABSTRACT:
SUBMITTER: Starke CE
PROVIDER: S-EPMC6994127 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Starke Carly E CE Vinton Carol L CL Ladell Kristin K McLaren James E JE Ortiz Alexandra M AM Mudd Joseph C JC Flynn Jacob K JK Lai Stephen H SH Wu Fan F Hirsch Vanessa M VM Darko Samuel S Douek Daniel C DC Price David A DA Brenchley Jason M JM
The Journal of clinical investigation 20200201 2
CD8+ T cell responses are necessary for immune control of simian immunodeficiency virus (SIV). However, the key parameters that dictate antiviral potency remain elusive, conceivably because most studies to date have been restricted to analyses of circulating CD8+ T cells. We conducted a detailed clonotypic, functional, and phenotypic survey of SIV-specific CD8+ T cells across multiple anatomical sites in chronically infected rhesus macaques with high (>10,000 copies/mL plasma) or low burdens of ...[more]