Ontology highlight
ABSTRACT:
SUBMITTER: Coss SL
PROVIDER: S-EPMC6994162 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Coss Samantha L SL Torres-Cornejo Almudena A Prasad Mona R MR Moore-Clingenpeel Melissa M Grakoui Arash A Lauer Georg M GM Walker Christopher M CM Honegger Jonathan R JR
The Journal of clinical investigation 20200201 2
Chronic hepatitis C virus (HCV) infection is characterized by persistent high-level viremia and defective cellular immunity, including a lack of functional HCV-specific CD4+ T cells. We previously described an exceptional period of viral control that occurs in some chronically infected women after childbirth. Here, we investigated whether reduced HCV replication after pregnancy is associated with recovery of CD4+ T cell immunity. Class II tetramer analysis revealed significantly greater frequenc ...[more]