Unknown

Dataset Information

0

Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea.


ABSTRACT: OBJECTIVES:Approximately 25% of patients with irritable bowel syndrome-diarrhea (IBS-D) have increased total fecal bile acids (BA) and serum C4 (surrogate for BA synthesis). BA synthesis-related genes (KLB and FGFR4) are associated with colonic transit (CT) in IBS-D. Our aims were: (i) to compare phenotype and pathophysiology in IBS-D patients with increased or normal fecal excretion or synthesis of BA; and (ii) to explore association of variations in two candidate bile-acid synthesis genes (KLB and FGFR4) in these two subgroups of IBS-D. METHODS:A total of 64 IBS-D patients underwent on one occasion: fasting serum C4 and FGF19, total fecal fat and BA excretion, CT, intestinal and colonic permeability, and candidate genotyping (rs17618244 (KLB), rs351855 (FGFR4)). Colonic sensation and tone were measured in 47 of the IBS-D patients. IBS-D subgroups were identified by fecal BA >2,337?mM per 48?h or by serum C4 >47.1?ng/ml. RESULTS:IBS-D patients with fecal BA >2,337?mM per 48?h (19/54) had significantly greater body mass index, fecal fat, percent chenodeoxycholic acid (CDCA) in feces, and intestinal permeability, and borderline increased CT (P=0.13). Those IBS-D patients with serum C4 >47.1?ng/ml (13/54) had increased total fecal BA excretion and borderline increased colonic permeability. Variants in genes involved in feedback regulation of BA synthesis (KLB, P=0.06 and FGFR4, P=0.09) were potentially associated with the subgroup with elevated serum C4. CONCLUSIONS:IBS-D with increased BA excretion or synthesis is associated with significant pathophysiological changes relative to patients with normal BA profile. BA diarrhea is identified more effectively with total fecal BA than with serum C4.

SUBMITTER: Camilleri M 

PROVIDER: S-EPMC6994231 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea.

Camilleri Michael M   Busciglio Irene I   Acosta Andres A   Shin Andrea A   Carlson Paula P   Burton Duane D   Ryks Michael M   Rhoten Deborah D   Lamsam Jesse J   Lueke Alan A   Donato Leslie J LJ   Zinsmeister Alan R AR  

The American journal of gastroenterology 20140729 10


<h4>Objectives</h4>Approximately 25% of patients with irritable bowel syndrome-diarrhea (IBS-D) have increased total fecal bile acids (BA) and serum C4 (surrogate for BA synthesis). BA synthesis-related genes (KLB and FGFR4) are associated with colonic transit (CT) in IBS-D. Our aims were: (i) to compare phenotype and pathophysiology in IBS-D patients with increased or normal fecal excretion or synthesis of BA; and (ii) to explore association of variations in two candidate bile-acid synthesis ge  ...[more]

Similar Datasets

| S-EPMC5401790 | biostudies-literature
| S-EPMC6934182 | biostudies-literature
| S-EPMC3565429 | biostudies-literature
| S-EPMC7676935 | biostudies-literature
| S-EPMC4491506 | biostudies-literature
| S-EPMC6068233 | biostudies-literature
| S-EPMC3920085 | biostudies-literature
| S-EPMC4893683 | biostudies-literature
| S-EPMC10949424 | biostudies-literature
| S-EPMC9875959 | biostudies-literature