Ontology highlight
ABSTRACT:
SUBMITTER: Parisi G
PROVIDER: S-EPMC6994533 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Parisi Giulia G Saco Justin D JD Salazar Felix B FB Tsoi Jennifer J Krystofinski Paige P Puig-Saus Cristina C Zhang Ruixue R Zhou Jing J Cheung-Lau Gardenia C GC Garcia Alejandro J AJ Grasso Catherine S CS Tavaré Richard R Hu-Lieskovan Siwen S Mackay Sean S Zalevsky Jonathan J Bernatchez Chantale C Diab Adi A Wu Anna M AM Comin-Anduix Begoña B Charych Deborah D Ribas Antoni A
Nature communications 20200131 1
Interleukin-2 (IL-2) is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities. NKTR-214 is a kinetically-engineered IL-2 receptor βγ (IL-2Rβγ)-biased agonist consisting of IL-2 conjugated to multiple releasable polyethylene glycol chains resulting in sustained signaling through IL-2Rβγ. We report that ACT supported by NKTR-214 increases the proliferation, homing and persistence of anti-tumor T cells compared to ACT ...[more]