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Paraneoplastic bullous pemphigoid - A sign of clear cell renal carcinoma.


ABSTRACT: Paraneoplastic bullous pemphigoid is a rare paraneoplastic syndrome. Rash is pruritic, with erythematous eruption of large subepidermal bullae over skin and often mucosal surfaces. We present an 84y woman with a three week history of erythematous rash, and 48hrs of bullae. A left clear cell renal cell carcinoma was identified on CT imaging during the presentation. Subsequent removal of the tumour resulted in resolution of bullous pemphigoid symptoms. This first-of-kind case and successful result strengthens the association between renal cell carcinoma and paraneoplastic bullous pemphigoid, arguing for a high degree of clinical suspicion in unexplained presentations of bullous pemphigoid.

SUBMITTER: Jackson SR 

PROVIDER: S-EPMC6994537 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Paraneoplastic bullous pemphigoid - A sign of clear cell renal carcinoma.

Jackson Stuart R SR   Koestenbauer Jakob J   Carroll Adam P AP   Oo Than-Htike TH   Chou Shaun S   Indrajit Balasubramaniam B  

Urology case reports 20200113


Paraneoplastic bullous pemphigoid is a rare paraneoplastic syndrome. Rash is pruritic, with erythematous eruption of large subepidermal bullae over skin and often mucosal surfaces. We present an 84y woman with a three week history of erythematous rash, and 48hrs of bullae. A left clear cell renal cell carcinoma was identified on CT imaging during the presentation. Subsequent removal of the tumour resulted in resolution of bullous pemphigoid symptoms. This first-of-kind case and successful result  ...[more]

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