Dataset Information

Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival.

ABSTRACT:

Purpose

To report on the oncological outcome of organ-sparing surgery (OSS) compared to (total or partial) penectomy regarding recurrence patterns and survival in squamous cell carcinoma (SCC) of the penis.

Methods

This was a retrospective study of all patients with penile SCC and eligible follow-up data of at least 2 years at our institution. Patients with tumors staged???pT1G2 underwent invasive lymph node (LN) staging by dynamic sentinel-node biopsy or modified inguinal lymphadenectomy. Radical inguinal lymphadenectomy was performed when LNs were palpable at diagnosis and in those with a positive LN status after invasive nodal staging. Follow-up visits were assessed, and local, regional and distant recurrences were defined and analyzed.

Results

55 patients were identified with a mean follow-up of 63.7 months. Surgical management was OSS in 26 patients (47.2%) and partial or total penectomy in 29 cases (52.8%). Histopathological staging was: pTis (12.7%), pTa (16.3%), pT1a (18.2%), pT1b (5.5%), pT2 (29.1%) and pT3 (18.2%), respectively. Patients in the penectomy group were significantly older (mean 68 vs. 62 years; p?=?0.026) with a higher rate of advanced tumor stage (??pT2: 44.8% vs. 11.5%; p?=?0.002). The local recurrence rate was 42.3% (n?=?11) following OSS compared to 10.3% (n?=?3) after penectomy (p?=?0.007). Kaplan-Meier curves showed no significant differences between the two groups regarding metastasis-free and overall survival.

Conclusions

OSS is associated with a higher local recurrence rate compared to penectomy, yet it has no negative impact on overall and metastasis-free survival.

SUBMITTER: Lindner AK

PROVIDER: S-EPMC6994547 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival.

Lindner Andrea Katharina AK Schachtner Gert G Steiner Eberhard E Kroiss Alexander A Uprimny Christian C Steinkohl Fabian F Horninger Wolfgang W Heidegger Isabel I Madersbacher Stephan S Pichler Renate R

World journal of urology 20190506 2

<h4>Purpose</h4>To report on the oncological outcome of organ-sparing surgery (OSS) compared to (total or partial) penectomy regarding recurrence patterns and survival in squamous cell carcinoma (SCC) of the penis.<h4>Methods</h4>This was a retrospective study of all patients with penile SCC and eligible follow-up data of at least 2 years at our institution. Patients with tumors staged ≥ pT1G2 underwent invasive lymph node (LN) staging by dynamic sentinel-node biopsy or modified inguinal lymphad ...[more]

PMID: 31062123

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Dataset Information

Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival.

Purpose

Methods

Results

Conclusions

Publications

Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival.

Similar Datasets

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