Surface protein imputation from single cell transcriptomes by deep neural networks.
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ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC6994606 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Surface protein imputation from single cell transcriptomes by deep neural networks.
Zhou Zilu Z Ye Chengzhong C Wang Jingshu J Zhang Nancy R NR
Nature communications 20200131 1
While single cell RNA sequencing (scRNA-seq) is invaluable for studying cell populations, cell-surface proteins are often integral markers of cellular function and serve as primary targets for therapeutic intervention. Here we propose a transfer learning framework, single cell Transcriptome to Protein prediction with deep neural network (cTP-net), to impute surface protein abundances from scRNA-seq data by learning from existing single-cell multi-omic resources. ...[more]
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