Ontology highlight
ABSTRACT:
SUBMITTER: Pous L
PROVIDER: S-EPMC6994610 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200131 1
Neural stem/progenitor cells (NSPCs) originating from the subventricular zone (SVZ) contribute to brain repair during CNS disease. The microenvironment within the SVZ stem cell niche controls NSPC fate. However, extracellular factors within the niche that trigger astrogliogenesis over neurogenesis during CNS disease are unclear. Here, we show that blood-derived fibrinogen is enriched in the SVZ niche following distant cortical brain injury in mice. Fibrinogen inhibited neuronal differentiation i ...[more]